A 12-year-old girl who developed a typical Kluver-Bucy syndrome (KBS) following heat stroke is reported from the University of Minnesota and Gillette Children’s Hospital, Minneapolis, MN. The child collapsed and had a 20 min generalized seizure at the end of a 2 mile race run in 40-44 C ambient temperature. Cardiopulmonary resuscitation was necessary during a brief apnea. After iced normal saline infused during transport to the ER her rectal temperature was 102.7 F. Twelve days later she had bowel and bladder incontinence, her affect was flat, she examined objects orally and attempted to eat them, she had no language and could not imitate sounds or words, she could not identify objects, she did not recognize family members, she had marked motor restlessness. After 4 weeks, she was extremely distractible and had limited visual attention. She was unable to dress herself. She was absorbed with her body. Hypersexuality was demonstrated by moving and dancing suggestively, masturbating, and rubbing against objects. She attempted to sit on the lap of adults and to kiss adults of both sexes. Several weeks later, she developed aggressive behaviors. At discharge, she required constant supervision and was dependent on others for all daily needs. MRI at 11 months after heat stroke showed mild, diffuse atrophy. Fourteen months after onset, she did not respond consistently to language, did not communicate verbally, and was dependent on others. 
COMMENT. The features of Kluver-Bucy syndrome include visual agnosia, hypermetamorphosis (distortion of objects), hypersexuality, language disorder and aphasia, hyperorality, placidity, flat affect, and memory dysfunction. The authors concluded that a metabolic/anoxic encephalopathy associated with heat stroke was the cause of the KBS in this child. In 12 additional reports cited from the literature, anoxic encephalopathy was the most commonly identified cause.
This article is especially appropriate during this exceptionally hot summer. Young athletes should be warned of possible serious consequences of exercise and heat stroke.