The efficacy of bupropion and methylphenidate in the treatment of ADHD was compared in a double-blind, crossover study of 15 patients (7 to 17 years of age) at the University of Iowa, Iowa City. Methylphenidate titrated from 0.4 to 1.3 mg/kg per day (mean 0.7 mg/kg/d) and bupropion 1.4 to 5.7 mg/kg/d (mean 3.3 mg/kg/d) over a 6 week period were followed by a 2 week wash out period. Both drugs were effective in the treatment of ADHD, but rating scales trended in favor of methylphenidate. [1]

COMMENT. Side effects were minor with either drug in this study.