The efficacy of bupropion and methylphenidate in the treatment of ADHD was compared in a double-blind, crossover study of 15 patients (7 to 17 years of age) at the University of Iowa, Iowa City. Methylphenidate titrated from 0.4 to 1.3 mg/kg per day (mean 0.7 mg/kg/d) and bupropion 1.4 to 5.7 mg/kg/d (mean 3.3 mg/kg/d) over a 6 week period were followed by a 2 week wash out period. Both drugs were effective in the treatment of ADHD, but rating scales trended in favor of methylphenidate. 
COMMENT. Side effects were minor with either drug in this study.