Four out of 380 HIV-infected children followed in a 10 year period at the Hopital Bicetre, France, had acute hemiparesis and stroke with MRI and CT evidence of cerebral infarcts. Two patients had giant aneurysms and multiple thromboses, a history of frequent infections, a severe clinical course, and poor or fatal outcome. Two had an isolated thrombosis or necrotic area, a less progressive disease, and a more favorable outcome. In two additional patients, stroke was secondary to a massive cerebral hemorrhage and thrombocytopenia, and to sickle cell disease. [1]

COMMENT. Stroke in HIV infected children is rare but variable in underlying pathology and prognosis. The authors anticipate a more frequent incidence of this complication because of improved management and longer survival of patients with HIV.