A case of a healthy young man who developed seizures and generalized paroxysmal fast activity in the EEG following use of propofol for anesthesia in minor surgery is reported from the Department of Neurology, University of South Alabama, Mobile, AL. Myoclonic jerking and obtundation developed shortly after anesthesia and a generalized seizure associated with EEG paroxysmal fast activity and controlled with divalproex occurred the following day. [1]

COMMENT. Propofol anesthesia has been associated with seizures, myoclonic jerking and opisthotonic posturing. Spikes, polyspikes and spike wave complexes in the EEG have also been reported. The fast activity in the EEG in the above case was considered to be epileptiform, resolving after short-term anticonvulsant therapy.