Results of a multicenter randomized trial of low-dose indomethacin (0.1 mg/kg IV) in prevention of intraventricular hemorrhage (IVH) in very low birth weight infants are reported from Yale New Haven Hospital, CT; Brown University, Providence, RI; and Maine Medical Center, Portland, ME. The incidence and severity of IVH were significantly lowered. Of 431 neonates enrolled, 25 (12%) treated and 40 (18%) controls developed IVH. Grade 4 IVH occurred in only 1 indomethacin-treated neonate and in 10 placebo-treated controls. 
COMMENT. Volpe JJ, Harvard Medical School, and Reynolds EOR and Meek J, University College, London, are concerned about the cerebral vasoconstrictor effects of indomethacin and the dangers of periventricular ischemic injury . These authorities are reluctant to endorse wholesale treatment of low birth weight newborns with indomethacin.