Seven of 10 patients with infantile spasms examined by SPECT at Tokushima University School of Medicine, Japan, showed localized cerebral hypoperfusion in the temporal lobes. EEGs near time of SPECT showed corresponding focal abnormalities in 5. The MRI was less revealing, with confirmation of localized lesions in only 3. [1]

COMMENT. Infantile spasms may be associated with focal temporal lobe hypoperfusion on SPECT despite normal MRI.

PET studies of infantile spasms have also shown focal abnormalities when MRI was normal. [2]