The Diagnostic Criteria Committee of the National Tuberous Sclerosis Association reports primary, secondary, and tertiary features of the disease complex and considers the specificity and reliability of the various lesions. The histological pattern of a lesion when available is generally more reliable than visual or radiographic appearances. Definite, probable and suspect diagnoses are categorized. [1]

COMMENT. In an editorial, Dr. Robert M. Shuman notes that assumptions about the specificity of lesions will need to be tested. The Committee intends these criteria to be adaptable and modified as data are collected.