Refractory absence epilepsy in 4 children was treated with amantadine as an add-on drug at the Tel Aviv University Sackler School of Medicine, Israel. The patients responded within 1 week and remained free of symptoms for 27-36 months without adverse effects. The dosage was 5-7 mg/kg per day given twice a day up to a maximum of 200 mg daily. 
COMMENT. Amantadine was initially used by Shields et al. in the treatment of 10 children with minor motor seizures refractory to medications. Myoclonic seizures and atypical absence seizures responded well.