Feeding problems, dietary intake and the growth and nutrition of 10 girls with Rett syndrome were reported from the University of Oslo, Norway. All patients had birth weight and length within the normal range until 6 to 24 months of age. A fall off in linear growth occurred in the first 2 years of life, and at follow-up between 3 and 16 years of age, all but 1 had height and/or weight below the 2.5 percentile of healthy children. Oral-motor dysfunctions were common. The mean energy intake was 70% of the U.S. recommendations according to age and 108% according to body weight. The intakes of thiamin, vitamin D, calcium and iron were low. None was anemic. 
COMMENT. The authors conclude that feeding problems and inadequate intake of nutrients contribute to the poor weight and growth of girls with Rett syndrome. Consultation with a dietician is important in children with Rett syndrome.
Rett syndrome in a pair of full sisters is reported from Sao Paulo, Brazil . The occurrence of familial cases is very rare and up to now, 3 pairs of full sisters, 2 pairs of half sisters, and 1 aunt/niece pair had been reported. All 2 pairs of female dizygotic twins have been discordant and all 8 pairs of monozygotic twins have been concordant for the disease. The parents of the reported sisters with Rett syndrome were unrelated.