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Seizure Disorders

Continuous EEG in Critically Ill Children

Authors:

Jonathan E Kurz,

Northwestern University Feinberg School of Medicine, US
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Mark S Wainwright

Northwestern University Feinberg School of Medicine, US
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Abstract

Investigators from the Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society reported a consensus statement on indications for the use of critical care continuous electroencephalographic monitoring (ccEEG) in adults and children.
How to Cite: Kurz, J.E. and Wainwright, M.S., 2015. Continuous EEG in Critically Ill Children. Pediatric Neurology Briefs, 29(3), p.20. DOI: http://doi.org/10.15844/pedneurbriefs-29-3-3
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  Published on 29 Mar 2015
 Accepted on 22 Mar 2015            Submitted on 18 Mar 2015

Investigators from the Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society reported a consensus statement on indications for the use of critical care continuous electroencephalographic monitoring (ccEEG) in adults and children [1]. The consensus statement is based on observational trials and expert opinion, and defines indications for ccEEG with the goal of early identification and treatment of neurologic pathologies that might not be apparent by clinical exam alone. This statement also provides recommendations for ccEEG duration, as well as review and interpretation frequency. ccEEG is recommended for the identification of non-convulsive seizures (NCS) and non-convulsive status epilepticus (NCSE) [2]. Specific populations at risk for NCS or NCSE include patients with persistent alteration of mental status after an acute supratentorial brain injury, after generalized convulsive status epilepticus or clinical seizures, or with encephalopathy of unknown etiology. ccEEG is also recommended in at-risk patients that require pharmacologic neuromuscular blockade, in patients with periodic discharges on a routine or emergent EEG, and for titration of continuous intravenous anticonvulsants or pharmacologically-induced coma.

Assessment of the electrographic background with ccEEG may also help predict outcome in a range of acute neurologic conditions, and could allow for early detection and treatment of cerebral ischemia in at-risk patients. ccEEG recording for at least 24 hours is recommended in most cases, although the authors acknowledge that there may be situations where shorter or longer periods of recording are necessary. Review of ccEEG by technologists is suggested as often as feasible, with interpretation by neurophysiologists at least twice daily. [1]

COMMENTARY. Observational studies in both pediatric and adult intensive care units have found frequent NCS and NCSE in critically ill patients, with rates of electrographic seizure ranging from 10 to 40% in children [3, 4]. While the use of ccEEG is increasing, ccEEG indications, duration and review frequency vary considerably between institutions [5]. In part, this reflects the limitations of the current literature; although studies suggest an association between electrographic seizure burden and poor outcomes in critically ill children [6], no randomized, controlled trials have examined the impact of ccEEG use on seizure control or patient outcomes. ccEEG can be resource-intensive, and institutions have developed varying strategies for the allocation of these resources in the absence of high-quality data to guide patient management.

This consensus statement provides a valuable starting point for development of ccEEG protocols based on the best currently available evidence. The clinical impact of ccEEG on seizure management and patient outcome remains an important area of ongoing research.

Disclosures

The author(s) have declared that no competing interests exist.

References

  1. Herman, ST Abend, NS Bleck, TP Chapman, KE Drislane, FW Emerson, RG et al. (2015). Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part I: Indications. J Clin Neurophysiol, DOI: https://doi.org/10.1097/wnp.0000000000000166 [PubMed] Epub 2015/01/30. 

  2. Abend, NS Arndt, DH Carpenter, JL Chapman, KE Cornett, KM Gallentine, WB et al. (2013). Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology 81(4): 383–91, DOI: https://doi.org/10.1212/WNL.0b013e31829c5cfe [PubMed]  

  3. Abend, NS, Wusthoff, CJ, Goldberg, EM and Dlugos, DJ (2013). Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol 12(12): 1170–9, DOI: https://doi.org/10.1016/S1474-4422(13)70246-1 [PubMed]  

  4. Piantino, JA Wainwright, MS Grimason, M Smith, CM Hussain, E Byron, D et al. (2013). Nonconvulsive seizures are common in children treated with extracorporeal cardiac life support. Pediatr Crit Care Med 14(6): 601–9, DOI: https://doi.org/10.1097/PCC.0b013e318291755a [PubMed]  

  5. Abend, NS, Dlugos, DJ, Hahn, CD, Hirsch, LJ and Herman, ST (2010). Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care 12(3): 382–9, DOI: https://doi.org/10.1007/s12028-010-9337-2 [PubMed]  

  6. Payne, ET Zhao, XY Frndova, H McBain, K Sharma, R Hutchison, JS et al. (2014). Seizure burden is independently associated with short term outcome in critically ill children. Brain 137(Pt 5): 1429–38, DOI: https://doi.org/10.1093/brain/awu042 [PubMed]  


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