Investigators at the Mott Children’s Hospital, Ann Arbor, MI, report 4 infants with diffuse brain injury and cerebral atrophy who developed cerebral venous sinus thrombosis and were treated with the low-molecular-weight heparin, enoxaparin. The infants subsequently developed subdural hemorrhages, diagnosed on routine MRI, and one had focal seizures. The use of enoxaparin in infants with diffuse brain injury has a risk of intracranial subdural hemorrhage. [1]

COMMENTARY. Asymptomatic subdural hematomas are common in infants with congenital heart disease and they resolve within 3 months of birth [2].