Clinicians from the Child Neurology Division, Sapienza University of Rome, and 7 other pediatric neurology centers in Italy report a series of 19 Sotos syndrome (SS) patients with febrile seizures (FS) and/or epilepsy during childhood and a long-term follow-up. Fifteen patients were male and 4 female. Mean age at first evaluation was 5 years 2 months (range 4 months–15 years). Minimum follow-up period was 5 years (range 5-19 years). FS were recorded in 11(58%) patients and afebrile seizures (AFS) in 15 (79%). FS were only simple in 6/11 (55%), only complex in 1 (9%), and both simple and complex in 4 (36%). AFS were temporal lobe type in 40%, and were responsive to AED therapy. All patients had the typical facial features of SS (high, broad forehead, down-slanting palpebral fissures, and pointed chin), tall stature and macrocephaly, and learning disability. Neurologic disorders associated with SS are hypotonia, incoordination, delayed language and motor development, behavioral abnormalities, and seizures. 
COMMENT. More than half of children with SS have FS and/or AFS, and more than half of those with FS develop epilepsy, temporal lobe type in 40%. Seizures in SS are usually responsive to AED monotherapy.