The association of severe or recurrent headache or migraine with vascular disease in childhood or adolescence was examined by a National Health and Nutrition Survey at the National Institute of Neurological Disease and Stroke and of Mental Health, Bethesda, MD. Children with headaches had higher mean values for body mass index, C-reactive protein, and homocysteine, and more children with headaches were at the highest risk for these factors. Serum and red blood cell folate levels were lower in children with headache. 
COMMENT. Screening of children with recurrent headache for vascular disease risk factors may permit early preventive intervention for vascular disease.
Thrombophilia risk factor for arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children. Review and Meta-analysis. (Kenet G et al. Circulation April 12, 2010;published online. Respond: Ulrike Nowak-Gottl MD, E-mail: email@example.com). A multinational search of electronic databases for studies published from 1970 to 2009 found 22 of 185 references met inclusion criteria and included 1764 patients (1526 with arterial ischemic stroke [AIS], and 238 with cerebral sinovenous thrombosis [CSVT]) and 2799 controls. A statistically significant association with first stroke (AIS or CSVT) was demonstrated for each thrombophilia trait evaluated. These included antithrombin deficiency, protein C deficiency, protein S deficiency, factor V, factor H, and combined thrombophilias. Thrombophilias are risk factors for first incident stroke. Outcome and recurrence risk of stroke need further investigation.