Auditory and language processing in 17 subjects with autosomal dominant partial epilepsy with auditory features (ADPEAF) was investigated by MRI, fMRI, and MEG and compared to 26 controls, in a study at Columbia University, New York. Age of seizure onset was late childhood or adolescence. MRI revealed no structural abnormality, but fMRI and MEG showed reduced or delayed activation patterns in affected subjects. A previous report of a lateral temporal malformation in ADPEAF is not supported by this study, but the findings point to a functional impairment of language processing. [1]

COMMENT. Autosomal dominant partial epilepsy with auditory features is an idiopathic focal epilepsy syndrome with auditory symptoms or receptive aphasia. Families with this syndrome commonly have mutations in the LGI1 gene. These authors previously published a review of the genetics of 24 ADPEAF families with mutations in the LGI1 gene (Ped Neur Briefs Sept 2008;22:71).