Twenty seven consecutive patients diagnosed with brain tumor in the first year of life, between 1980 and 2005, were followed at the University Children's Flospital of Zurich, Switzerland. Of 11 survivors at mean follow-up of 12.3 years, 9 had persistent neurological complications, 4 had endocrine and growth complications, and 8 had cognitive deficits with school problems and poor occupation choices. Behavioral and psychological problems occurred in 7 patients, and health-related quality of life, especially social functioning, was generally impaired. Patients with high-grade tumor histology and intense therapy had the lowest quality of life. 
COMMENT. With long-term survival, the importance of quality of life issues is increased and requires early intervention. Children with brain tumors requiring treatment with radiotherapy are particularly prone to cognitive, behavioral and social problems.