The efficacy and safety of Adderall XR in the treatment of attention deficit/hyperactivity disorder and diurnal variation in responses were assessed by a multicenter, randomized, double-blind, parallel group, placebo-controlled trial at 47 sites, and reported from the Massachusetts General Hospital, Boston, MA. Patients received single-daily morning doses of placebo or Adderall 10, 20, or 30 mg for 3 weeks. In 509 children aged 6 to 12 years who completed the study, Intention-to-treat analysis of Conners Global Index Scales for Teachers and Parents revealed significant improvement in morning, afternoon, and late afternoon behavior for all active treatment groups versus placebo, significant dose-related improvements in behavior from baseline, and all doses were superior to placebo. Adverse events that occurred significantly more frequently with Adderall than placebo included anorexia, in 22% of participants, insomnia (17%), abdominal pain (12%), and emotional lability (9%). Anorexia was dose-related. The majority (69%) of adverse events were mild, 28% moderate, and 4% were severe. Nine Adderall-treated patients required withdrawal of medication because of anorexia, abdominal pain, or nausea. Laboratory values including ECG showed no significant changes. 
COMMENT. It is reassuring to know that the effectiveness of Adderall XR noted in clinical practice is confirmed in controlled trial.