Infants with persistent crying (PC) in the first 6 months (mean age 3.8 months) were reassessed at 8 to 10 years of age and compared with 64 classroom controls for hyperactivity, conduct problems and academic difficulties in a prospective study at the University of Hertfordshire, UK. Ten (19%) of 53 PC infants had pervasive hyperactivity, as reported by child, parent and teacher, compared with 1 of 62 controls, at school age. Parents and children but not teachers reported more conduct disorders. Parents rated temperament to be more negative in emotionality and difficult-demanding. Teachers reported significantly lower academic achievement in PC group, especially in those with hyperactivity. Infants with PC also had increased incidence of sleeping or feeding problems. 
COMMENT. Infants with persistent crying and associated sleeping or feeding problems are at risk for hyperactive behavior and learning difficulties in childhood.