The use of divalproex sodium (DVS) as a prophylactic treatment for migraine was studied in 42 patients, 7 to 16 years of age (mean age, 11.3 years) seen between July 1996 and December 1998 at St Jude Children’s Research Hospital, Memphis, TN; and Hasbro Children’s Hospital/Rhode Island Hospital,Divalproex Brown University, Providence, RI. After 4 months treatment with DVS in doses ranging from 15 to 45 mg/kg.day, 10% became headache-free, 14% had a 75% reduction. 78% a 50% reduction in headaches, and 80% were able to discontinue medicines used to abort attacks. Adverse effects included gastrointestinal upset, weight gain, somnolence, dizzinesss, and tremor. None had hepatotoxicity. 
COMMENT. In this uncontrolled trial, divalproex sodium was effective as a prophylactic therapy for childhood migraine.