Neurobehavioral deficits in the offspring of schizophrenic parents compared to offspring of parents with no or nonschizophrenic mental disorder were analyzed in 65 Israeli adolescents enrolled in the Jerusalem Infant Development Study. Poor neurobehavioral functioning, assessed by a battery of neurologic and neuropsychological tests and psychiatric interviews, was found in 42% (10/24) of offspring of schizophrenic parents (73% of the male offspring), compared to 22% (9/41) of offspring of nonschizophrenic parents. Poor psychiatric adjustment at adolescence was preceeded by problems at an earlier age. [1]

COMMENT. Neurobehavioral signs in infants, children and adolescents may be markers of vulnerability to schizophrenia and poor global psychiatric adjustment. Risk factors for development of schizophrenia in offspring of schizophrenics include motor and sensorimotor behavior problems during the first year of life and poor motor and cognitive functioning during school age. Male offspring are more susceptible than girls.

Chromosome anomaly in autism and epilepsy. A 12-year-old boy with atypical autism and epilepsy had a maternally derived duplication of chromosome 15qll-ql3. [2]