Three children, ages 9, 12 and 14 years, with acquired epileptic aphasia refractory to treatment with antiepileptic drugs, ACTH and prednisone, responded to the ketogenic diet for 12 to 26 months, in a trial at the Children’s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, PA. Improvements in language, and lessening of seizures and EEG seizure discharges occurred in all patients. Social interactions and behavior also improved significantly. [1]

COMMENT. The ketogenic diet is presented as a new therapeutic alternative for patients with Landau-Kleffner syndrome. The results are promising and the method deserves further study in this frequently resistant epileptic disorder.

Language dominance in epilepsy patients is studied using functional MRI at the Medical College of Wisconsin, Milwaukee, WI [2]. Compared to normal subjects considered left hemisphere dominant in 94%, there was greater variability of language dominance in the epilepsy group, 78% showing left hemisphere dominance, 16% a symmetric pattern and 6% right hemisphere dominance. Atypical language dominance in the epilepsy group was correlated with an earlier age of brain injury and with weaker hand dominance.