Serial analysis of imaging (thallium-201 [201TI) single-photon emission CT and MRI) examinations was correlated with clinical and histological characteristics of brain tumors in 75 patients monitored for 1 day to 3.9 years (mean, 1.39 years) at the Children’s Hospital, Harvard Medical School, Boston. Abnormal 201TI uptake was associated with greater mortality and morbidity: 17% of 201TI-positive patients died, whereas no deaths occurred in 201TI-negative groups. A survival period of >2 years from diagnosis occurred in only one 201TI-positive patient, in contrast to almost one half of the 201TI-negative group. Significant enhancement of lesions with paramagnetic contrast agents correlated with greater mortality, whereas no deaths occurred in those lacking abnormal enhancement. 
COMMENT. Neuroimaging 201TI activity may predict brain tumor outcome.