Benefits from treatment of mitochondrial encephalomyopathy (MEM) with cytochrome C (6.25 mg) and vitamins B1 (25 mg) and B2 (12.5 mg), in daily injections, are reported from Osaka University Medical School and other centers in Japan. Symptomatic improvements in 8 of 9 patients included decrease in muscle fatigability, and lessening of motor disability and severity of stroke-like episodes. Intermittent courses of injections were needed to maintain clinical improvement. 
COMMENT. The authors advocate a trial of cytochrome C/vitamin B treatment in children with MEM; disease progression is not halted but symptoms may be ameliorated.