Two children, ages 3 and 11, who developed multiorgan dysfunction and disseminated intravascular coagulation (DIC) 9 days after the addition of lamotrigine to valproic acid anticonvulsant therapy are reported from the Hospital for Sick Children, Toronto, Canada. Both children developed a flu-like illness with fever, urticarial/maculopapular rash, hepatic and renal dysfunction, hypoalbuminemia, DIC, and one had rhabdomyolysis while being seizure-free. [1]