The safety of antiepileptic drug (AED) withdrawal in 65 children with cerebral palsy (CP) who had been seizure-free for at least 2 years was investigated in the Neurology Department, Texas Scottish Rite Hospital for Children, Dallas. Seizure relapses occurred in 27 patients (41%). Those with spastic hemiparesis had the highest relapse rate (61%) and spastic diplegia was associated with the lowest rate (14%). Mental subnormality, epileptiform EEG abnormality, type of CT abnormality, family history of epilepsy, mono or polytherapy, and gender were not correlated with risk of seizure relapse. 
COMMENT. Despite abnormal neurologic examinations, almost two thirds of these CP patients remained free from seizures for periods of at least 2 years after AED withdrawal. Patients with spastic hemiparesis have the highest relapse rate, and drug withdrawal should be discouraged or attempted only with great caution.