MRI studies in 26 patients, ages 3 to 25 years, with subacute sclerosing panencephalitis (SSPE) are reported from the Departments of Pediatric Neurology and Radiology, Hacettepe University, and SSK Ankara Hospital, Ankara, Turkey. Lesions of high signal intensity on T2-weighted images were present in the cerebral cortex and subcortical and periventricular white matter. A local mass effect occurred in 5 patients. White matter involvement extended to the splenium of the corpus callosum, whereas basal ganglia, thalamic nuclei, and brainstem were spared. Parenchymal lesions had a weak correlation with clinical symptoms and signs, especially motor and visual symptoms. Periventricular lesions and cerebral atrophy showed no clinical correlation. 
COMMENT. The MRI may be helpful in the diagnosis of SSPE. The presenting symptoms are usually myoclonic jerks and mental deterioration. A positive titer of measles antibodies in the CSF and a characteristic EEG are additional manifestations.