Grading and localization of 67 intracranial ependymomas operated on in children less than 15 years of age from 1951 to 1990 were correlated with prognosis in a retrospective study at the University of Koln, Germany. Grade II ependymomas (38) were located in the IV ventricle and supratentorial midline, making complete removal impossible. The majority of grade III anaplastic, malignant tumors (28) were in the cerebral hemispheres and were totally removed. Operative mortality was higher in grade II than grade III. Median progression-free survival time was 120 months for grade II and 18 months for grade III ependymomas. [1]

COMMENT. As might be expected, the progression-free survival time is longer for the grade II ependymomas than the anaplastic grade III tumors, despite incomplete operative removal of the less malignant type.

Prognosis of cerebral oligodendrogliomas is studied in 15 children operated on at the Hopital Pierre Wertheimer, Lyon, France. Two groups were recognized: 1). Seven presenting with epilepsy had benign tumors and all survived at 72-month follow-up; 2). Eight presenting with intracranial hypertension had malignant anaplastic tumors, and 6 died within 17 months despite postoperative radiotherapy and chemotherapy. Clinical presentation and histology were correlated with survival time. [2]