The effects of convulsion and fever on the CSF and blood glucose concentrations in febrile and non-febrile children, with and without convulsions, have been studied at the Department of Paediatrics, Kuopio University Hospital and Department of Pharmacology and Toxicology, University of Kuopia, Kuopio, Finland. The concentration of glucose in the CSF was significantly higher in febrile children with and without convulsions than in non-febrile, non-convulsive children. Both fever and convulsions increased the CSF glucose levels. The body temperature plotted against the CSF glucose showed a linear correlation. Blood glucose parallelled CSF levels in all groups. Hyperglycemia and elevated CSF glucose in febrile convulsions are apparently secondary to both the fever and convulsion, not the convulsion alone. [1]

COMMENT. Of 110 patients with febrile seizures examined personally, the cerebrospinal fluid was essentially normal in 86 tested. The concentration of sugar was greater than 80 mg/100 ml in 24 patients and 100 mg/100 ml or higher in 11. (Millichap JG et al. 1960). A review of the literature in the 1960s revealed 18 publications between 1934 and 1964, which included the CSF findings of 500 children with febrile convulsions. Elevations of CSF sugar were found in only three reports, in addition to my own study, the first in 1938, and these involved 37 of 68 patients tested [2]. The present study attempts to elucidate the mechanism of the increased CSF sugar concentration found in some children with febrile convulsions. Both fever and convulsion were found to have a role in elevating the CSF sugar levels.